Neurodegenerative changes initiated by presynaptic dysfunction
作者机构：Department of NeurologyOsaka University Graduate School of MedicineSuitaOsakaJapan Present address:Department of GeneticsNational Center for Child Health and DevelopmentSetagaya-kuTokyoJapan
出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)
年 卷 期：2013年第2卷第1期
页 面：108-112页
基 金：This work was supported by Grants from the Japan Science and Technology Agency(JST),Core Research for Evolutional Science and Technology(CREST)(to H.M.) Grants-in-Aid from the Research Committee of CNS Degenerative Diseases,the Ministry of Health,Labour and Welfare of Japan(to H.M.) a Research Grant for Longevity Sciences from the Ministry of Health,Labour and Welfare of Japan(to H.M.) grants(#S0801035)from the Ministry of Education,Culture,Sports,Science,and Technology(MEXT)of Japan(to H.M.) and Grant-in-Aid for Scientific Research on Innovative Areas(Comprehensive Brain Science Network)from the Ministry of Education,Science,Sports and Culture of Japan(to H.M.)
主 题：degenerative dysfunction involvement
摘 要：α-Synucleinopathies are a subgroup of neurodegenerative diseases including dementia with Lewy bodies(DLB)and Parkinson’s disease(PD).Pathologically,these disorders can be characterized by the presence of intraneuronal aggregates composed mainly of α-synuclein(αSyn),which are called Lewy bodies and Lewy *** report showed that more than 90% of αSyn aggregates are present in the form of very small deposits in presynaptic terminals of the affected neurons in ***,the mechanisms responsible for presynaptic accumulation of abnormal αSyn remain *** this article,we review recent findings on the involvement of presynaptic dysfunction in the initiation of neuronal dysfunctional *** review highlights that the presynaptic failure can be a potential trigger of the dying-back neuronal death in neurodegenerative diseases.
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