Kaposi肉瘤相关疱疹病毒血症与经典型及地方型Kaposi肉瘤进展相关

作     者：Pellet C. Kerob D. Dupuy A. C. Lebbé 吴佳纹 

作者机构：Policlinique de DermatologieSaint-Louis 1 avenue Claude Vellefaux 75475 Paris Cedex 10 France Prof. 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第5期

页      面：18-18页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：经典型 Kaposi 疱疹病 毒血症 循环内皮细胞 外周血单核细胞 方型 梭形细胞 免疫学 稳定期 

摘      要：In order to gain further insight on the role of Kaposi’ s sarcoma associated herpesvirus (KSHV) in classic and endemic Kaposi’ s sarcoma (KS) pathogenesis, we aimed to determine (i) whether KSHV is detectable in peripheral blood mononuclear cells (PBMCs), (ii) which PBMCs subpopulation harbor the virus, (iii) which clinical, histologic, and immunologic parameters are associated with KSHV viremia in a population of classic and endemic KS. KSHV viremia and various immunologic parameters were screened on 81 patients. KSHV viremia was positive in 58% of the patients. KSHV was detected in B cells, T cells, and monocytes. CD34+ cells depleted in circulating endothelial cells (CECs) were never infected and 50% of the patients tested had CECs infected by KSHV. We observed a significant increase of IL-2 and IFN-γ production by CD4 T cells and an increase of IFN-γ production by CD8 T cells compared to control patients. KS progression (P=0.001) and KS staging (P=0.03) were significantly and independently associated with positive KSHV viremia. Our results show that there is no specific immunosuppression in classic or endemic KS. We showed that KSHV can be detected within CECs and that KSHV viremia could be an indicator of circulating mature or precursor spindle cells.