根治幽门螺杆菌感染对胃食管反流病的影响

作     者：Güliter S. Kandilci U. 赵丽娜 

作者机构：Aydinlikevler Mah. Ekim Sok 5/4 06130 Ankara TurkeyDr. 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2005年第1卷第2期

页      面：54-54页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：胃食管反流 食管内压力测定 兰索拉唑 胃灼热 羟氨苄青霉素 快速尿素酶试验 平均静息压力 胃体部 活检组织 病理学检查 

摘      要：Background: The effect of Helicobacter pylori (H. pylori) eradication on gastr oesophageal reflux disease is controversial. We aimed to investigate the effect of H. pylori eradication in this group of patients. Materials and Methods: Thirt y-four consecutive patients with H. pylori infection and reflux esophagitis (gr ade 1 or 2) were enrolled into the study. Twenty-four hour intra-esophageal pH recording and esophageal manometry were performed before and 3 months after era dication of H. pylori, which was achieved using lansoprazole 30 mg b.i.d., amoxy cillin 1 g b.i.d., and clarithromycin 500 mg b.i.d. for 14 days. H. pylori was e valuated in biopsy specimens taken from the antrum and corpus by rapid urease te st and by histopathologic examination before and 3 months after eradication. Res ults: Eighteen patients (11 men and 7 women, median age 42 years) completed the study. Three months after the treatment, there was no significant change in any of the 24-hour esophageal pH recording parameters and mean lower esophageal sph incter resting pressure (P 0.05). The percentage of total time esophageal pH 4 increased in 10 patients, and decreased in 8 patients. There was a significant decrease in the scores of heartburn and regurgitation (P 0.01). Esophagitis p ersisted in 16 patients and disappeared in 2 patients. Esophagitis score decreas ed in 6 patients, and did not change in 12 patients (P 0.05). Conclusion: H. p ylori eradication does not have any effect on gastroesophageal acid reflux in pa tients with reflux esophagitis 3 months after eradication, but significant impro vement is achieved in some reflux associated symptoms.