The myelin membrane-associated enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase:on a highway to structure and function

作     者：Arne Raasakka Petri Kursula 

作者机构：Department of Biochemistry and Biocenter OuluUniversity of OuluOuluFinland Department of ChemistryUniversity of HamburgHamburgGermany 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2014年第30卷第6期

页      面：956-966页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from the Department of Biochemistry,University of Oulu the Sigrid Jusélius Foundation (Finland) the Academy of Finland the Hamburg Research and Science Foundation (Germany) 

主　　题：2′,3′-cyclic nucleotide 3′-phosphodiesterase calmodulin central nervous system cytoskeleton myelin proteins RNA 

摘      要：The membrane-anchored myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase（CNPase） was discovered in the early 1960 s and has since then troubled scientists with its peculiar catalytic activity and high expression levels in the central nervous system. Despite decades of research, the actual physiological relevance of CNPase has only recently begun to unravel. In addition to a role in myelination, CNPase is also involved in local adenosine production in traumatic brain injury and possibly has a regulatory function in mitochondrial membrane permeabilization. Although research focusing on the CNPase phosphodiesterase activity has been helpful, several open questions concerning the protein function in vivo remain unanswered. This review is focused on past research on CNPase, especially in the fields of structural biology and enzymology, and outlines the current understanding regarding the biochemical and physiological significance of CNPase, providing ideas and directions for future research.