Morphological differences in skeletal muscle atrophy of rats with motor nerve and/or sensory nerve injury

作     者：Lei Zhao Guangming Lv Shengyang Jiang Zhiqiang Yan Junming Sun Ling Wang Donglin Jiang 

作者机构：Department of Orthopedics Third Affiliated Hospital of Nantong University Wuxi 214041 Jiangsu Province China Key Laboratory of Neural Regeneration of Jiangsu Province Nantong University Nantong 223001 Jiangsu Province China Central Laboratory Third Affiliated Hospital of Nantong University Wuxi 214041 Jiangsu Province China Laboratory of Mechanical Biology and Medical Engineering Shanghai Jiao Tong University School of Medicine Shanghai 200030 China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第32期

页      面：2507-2515页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 071003[理学-生理学] 

基　　金：supported by Clinical Scientific Research Foundation of Nantong University  No. 200626 

主　　题：simple nerve injury muscular atrophy ultrastructure motor end plate rats neural regeneration 

摘      要：Skeletal muscle atrophy occurs after denervation. The present study dissected the rat left ventral root and dorsal root at L4-0 or the sciatic nerve to establish a model of simple motor nerve injury, sensory nerve injury or mixed nerve injury. Results showed that with prolonged denervation time, rats with simple motor nerve injury, sensory nerve injury or mixed nerve injury exhibited abnormal behavior, reduced wet weight of the left gastrocnemius muscle, decreased diameter and cross-sectional area and altered ultrastructure of muscle cells, as well as decreased cross-sectional area and increased gray scale of the gastrocnemius muscle motor end plate. Moreover, at the same time point, the pathological changes were most severe in mixed nerve injury, followed by simple motor nerve injury, and the changes in simple sensory nerve injury were the mildest. These findings indicate that normal skeletal muscle morphology is maintained by intact innervation. Motor nerve injury resulted in larger damage to skeletal muscle and more severe atrophy than sensory nerve injury. Thus, reconstruction of motor nerves should be considered first in the clinical treatment of skeletal muscle atrophy caused by denervation.