Juvenile hormone signaling-a mini review

作     者：Kang Li Qiang-Qiang Jia Sheng Li 

作者机构：Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and Technology&School of Life SciencesSouth China Normal UniversityGuangzhouChina 

出 版 物：《Insect Science》 (昆虫科学（英文版）)

年 卷 期：2019年第26卷第4期

页      面：600-606页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 09[农学] 0904[农学-植物保护] 0901[农学-作物学] 0713[理学-生态学] 

基　　金：support by the National Science Foundation of China(Grants No.31620103917,31330072,and 31572325 to SL,31702053 to KL) the National Science Foundation of Guangdong Province(Grants No.2017A030310270)to KL the Postdoctoral Foundation of China(Grant No.2017M610534 to KL and 2018M633068 to QJ) 

主　　题：intracellular receptor juvenile hormone (JH) Kr-h 1 membrane receptor Met/Gce metamorphosis reproduction 

摘      要：Since it was first postulated by Wigglesworth in 1934, juvenile hormone (JH) is considered a status quo hormone in insects because it prevents metamorphosis that is initiated by the molting hormone 20-hydroxyecdysone (20E). During the last decade, significant advances have been made regarding JH signaling. First, the bHLH-PAS transcription factor Met/Gce was identified as the JH intracellular receptor. In the presence of JH, with the assistance of Hsp83, and through physical association with a bHLH?PAS transcriptional co-activator, Met/Gce enters the nucleus and binds to E-box-like motifs in promoter regions of JH primary?response genes for inducing gene expression. Second, the zinc finger transcription factor Kr-hl was identified as the anti-metamorphic factor which transduces JH signaling. Via Kr-hl binding sites, Kr-hl represses expression of 20E primary?response genes (i.e. Bi\ E93 and E5) to prevent 20E-induced metamorphosis. Third, through the intracellular signaling, JH promotes differ ent aspects of female reproduction. Nevertheless, this action varies greatly from species to species. Last, a hypothetical JH membrane receptor has been predicted to be either a GPCR or a tyrosine kinase receptor. In future, it will be a great challenge to understand how the JH intracellular receptor Met/Gce and the yet unidentified JH membrane receptor coordinate to regulate metamorphosis and reproduction in insects.