Insulin-Enhanced Antitumor Effect of 5-Fluorouracil in vivo

作     者：Rui Wang Qingxia Fan Xiangjie Hu Liuxing Wang Peirong Zhao Ruilin Wang 

作者机构：The First Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China. Cancer research Center Zhengzhou University Zhengzhou 450052 Henan Province China. Department of Pharmacy Medical College Zhengzhou University Zhengzhou 450052 Henan Province. China. 

出 版 物：《Chinese Journal of Clinical Oncology》 (中国肿瘤临床（英文版）)

年 卷 期：2008年第5卷第4期

页      面：277-280页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by a grant from the Project for Science and Technology Creative Talents of Henan Province China(No.2005026) 

主　　题：5-氟二氧嘧啶 抗癌药 胰岛素 治疗方法 

摘      要：OBJECTIVE To determine if insulin treatment can enhance the antitumor effect of 5-fluorouracil(5-FU),and to explore the mech- anism of the enhancement of insulin. METHODS S180 sarcoma,H22 liver cancer and human Eca-109 esophageal cancer cells were transplanted into nude mice to evaluate the inhibitory effect on tumor growth of insulin alone or in combination with *** levels of serum insulin-like growth factor-I(IGF-I)and insulin-like growth factor binding protein-3 (IGFBP-3)were determined. RESULTS Compared with 5-FU treatment alone,the tumor weight of H22 liver cancer and S180 sarcoma was reduced further with high,medium and low-dose insulin(0.09,0.06,0.03 U/20 g) +5-FU *** a high dosage of insulin+5-FU was ad- ministered,tumor weight was significantly reduced(P0.05).In mice with H22 liver cancer and S180 sarcoma the IGF-1 level with high- dose insulin+5-FU treatment was significantly lower compared to treatment with 5-FU alone(P0.05),but the difference was not significant in mice transplanted with esophageal cancer cells. CONCLUSION Insulin can enhance the anti-tumor effect of 5-FU without significantly increasing 5-FU *** changes in the serum IGF-1 or IGFBP-3 level do not explain the mechanism of the insulin-induced enhancement on 5-FU on growth,a decrease in the level of serum IGF-1 and an increase in serum IGFBP-3 may be important in the chemotherapeutic response.