Necrotizing enterocolitis: A multifactorial disease with no cure

作     者：Kareena L Schnabl John E Van Aerde Alan BR Thomson Michael T Clandinin 

作者机构：Nutrition and Metabolism Research Groups Department of Medicine University of Alberta Edmonton T6G 2P5 Canada Department of Pediatrics University of Alberta Edmonton T6G 2P5 Canada Department of Medicine Division of Gastroenterology University of Alberta Edmonton T6G 2P5 Canada Alberta Institute for Human Nutrition University of Alberta Edmonton T6G 2P5 Canada 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第14期

页      面：2142-2161页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Canadian Institute of Health research grant, No. 143315, a National Sciences and Engineering Research Council scholarship 

主　　题：Necrotizing enterocolitis Diagnosis Pathogenesis Prevention Disease models Vasoactive/ inflammatory mediators 

摘      要：Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics.