Pulmonoprotective Action of Zataria multiflora Ethanolic Extract on Cyclophosphamide-Induced Oxidative Lung Toxicity in Mice

作     者：Emran Habibi Mohammad Shokrzadeh Amirhossein Ahmadi Aroona Chabra Farshad Naghshvar Hamed Haghi-AminjarP and Fatemeh Salehi Emran Habibi;Mohammad Shokrzadeh;Amirhossein Ahmadi;Aroona Chabra;Farshad Naghshvar;Hamed Haghi-Aminjan;Fatemeh Salehi

作者机构：Pharmaceutical Sciences Research CenterFaculty of PharmacyMazandaran University of Medical SciencesSari(48175-861)Iran Department of PharmacognosyFaculty of PharmacyMazandaran University of Medical SciencesSari(48175-861)Iran Department of Toxicology and PharmacologyFaculty of PharmacyMazandaran University of Medical SciencesSari(48175-861)Iran Student Research CommitteeFaculty of PharmacyMazandaran University of Medical SciencesSari(48175-861)Iran Department of PathologyFaculty of MedicineMazandaran University of Medical SciencesSari(48471-91971)Iran 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2020年第26卷第10期

页      面：754-761页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Student Research Committee Mazandaran University of Medical Sciences Sari Iran(No.92.60-92.90) 

主　　题：pulmonoprotective Zataria multiflora cyclophosphamide lung toxicity oxidative stress antioxidant activity 

摘      要：Objective To evaluate the protective effect of Zataria multiflora extract,an antioxidative medicinal plant,against cyclophosphamide(CP)-induced oxidative lung damage in *** Mice were intraperitoneally pre-treated with various doses of Zataria multiflora extract(50,100,200,and 400 mg/kg)once daily for 7 consecutive *** were then injected with a single 200 mg/kg intraperitoneal dose of CP 1 h after the last administration of ***-four hours later,mice were euthanized,the lungs were immediately removed,and biochemical and histological studies were *** A single dose of CP markedly altered the levels of several biomarkers associated with oxidative stress in lung *** with Zataria multiflora significantly inhibited the elevation of lipid peroxidation level and the depletion in glutathione content,and superoxide dismutase and catalase activities induced by CP in *** addition,Zataria multiflora effectively alleviated CP-induced histopathological abnormality and pulmonary damages in mice lung *** The results reveal that Zataria multiflora protects lung tissues from CP-induced toxicity and suggest a role for oxidative stress in the pathogenesis of lung toxicity produced by CP in *** Zataria multiflora has been extensively used as an additive agent and is regarded as safe,it may be used concomitantly as a good supplement for reducing organ toxicity in patients undergoing chemotherapy,besides their consolidated ethnopharmacological uses.