Sodium Amalgam, a Useful Reducing Reagent for Formation of Amines from Azides Bearing a Variety of Functional Groups

作     者：陆标 谢小安 朱继东 马大为 

作者机构：Department of Chemistry Fudan University Shanghai 200433 China State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2005年第23卷第12期

页      面：1637-1640页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 

基　　金：Project supported by the National Natural Science Foundation of China (No. 20132030) and the Science and Technology Commission of Shanghai Municipality (No.02JC14032) 

主　　题：sodium amalgam azides reduction 

摘      要：Reduction of azides to amines without touching benzyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, trityl and tetrahydropyranyl ether protecting groups, C-C double and triple bond, as well as aromatic bromide and nitrile functional groups, was achieved using sodium amalgam as a reducing reagent in methanol at temperature from -40℃ to room temperature. However, ester group was reduced under this condition.