Characteristics and prognosis of gastric cancer in patients aged ≥ 70 years
Characteristics and prognosis of gastric cancer in patients aged ≥ 70 years作者机构：Department of Gastric CancerTianjin Medical University Cancer Institute and HospitalKey Laboratory of Cancer Prevention and TherapyNational Clinical Research Center of Cancer Department of Cardiovascular Surgerythe First Hospital of Tianshui City
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2013年第19卷第39期
页 面：6568-6578页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Basic Research Program of China: 973 Program No. 2010CB529301
主 题：Gastric carcinoma Elderly patients Prognosis Lymphadenectomy Chemotherapy
摘 要：AIM:To elucidate the prognostic value of age for gastric cancer and identify the optimal treatment for elderly gastric cancer ***:We enrolled 920 patients with gastric cancer who underwent gastrectomy between January 2003and December 2007 in our *** were categorized into three groups:younger group(age50years),middle-aged group(50-69 years),and elderly group(≥70 years).Clinicopathological features were compared among the three groups and potential prognostic factors were *** log-rank test was used to assess statistical differences between *** prognostic factors were identified by the Cox proportional hazards regression *** analysis was used to investigate the impact of age on survival at each ***-specific survival was also compared among the three groups by excluding deaths due to reasons other than gastric *** analyzed the potential prognostic factors for patients aged≥***,the impact of extent of lymphadenectomy and postoperative chemotherapy on survival for each age group was ***:In the elderly group,there was a male *** the same time,cancers of the upper third of the stomach,differentiated type,and less-invasive surgery were more common than in the younger or middle-aged *** patients were more likely to have advanced tumor-node-metastasis(TNM)stage and larger tumors,but less likely to have distant *** 5-year overall survival(OS)rate specific to gastric cancer was not significantly different among the three groups,elderly patients demonstrated a significantly lower 5-year OS rate than the younger and middle-aged patients(elderly vs middle-aged vs younger patients=22.0%vs 36.6%vs 38.0%,respectively).In the TNM-stratified analysis,the differences in OS were only observed in patients withⅡandⅢ*** multivariate analysis,only surgical margin status,pT4,lymph node metastasis,M1 and sex were independent prognostic factors for
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