Aliphatic Halogenated Hydrocarbons: Report and Analysis of Liver Injury in 60 Patients

作     者：Rolf Teschke 

作者机构：Department of Internal MedicineⅡDivision of Gastroenterology and HepatologyKlinikum HanauHanauAcademic Teaching Hospital of the Medical FacultyGoethe University Frankfurt/MainFrankfurt/MainGermany 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2018年第6卷第4期

页      面：350-361页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Aliphatic halogenated hydrocarbons Dichloromethane Chloroform Carbon tetrachloride 1,2-dichloroethane 

摘      要：Background and Aims:Intoxications by aliphatic halogenated hydrocarbons(AHH),used as effective solvents,are rare and may cause life-threatening liver *** with acute intoxications by AHH received an innovative ***:Analyzed were data of 60 patients intoxicated by AHH,such as dichloromethane(n=3),chloroform(n=2),carbon tetrachloride(n=12),1,2-dichloroethane(n=18),1,1,2-trichloroethane(n=2),trichloroethylene(n=2),tetrachloroethylene(n=13)or mixed AHH chemicals(n=8),who received a new treatment consisting of CO2-induced hyperventilation to accelerate toxin removal via the ***:Added to the inspiration air at a flow rate of 2-3 Liter min-1,CO2 increased the respiratory volume up to 25-30 Liter min-1,ensuring forced AHH *** CO2-induced hyperventilation therapy was commonly well tolerated by the 60 patients and lasted for 106.0±10.5 *** most cases,initially increased liver test results of aminotransferases normalized quickly under the therapy,and liver histology obtained at completion of the therapy revealed,in the majority of patients,normal findings or fatty changes,and rarely severe single cell necrosis but no confluent liver cell *** therapy,clinical outcome was unfavorable for 4/60 patients(6.7%)of the study cohort,due to single or combined risk *** included late initiation of the CO2-induced hyperventilation therapy,intentional intoxication,uptake of high amounts of AHH,concomitant ingestion of overdosed drugs,consumption of high amounts of alcohol,and history of alcohol ***:For intoxications by AHH,effective therapy approaches including forced hyperventilation to increase toxin removal via the lungs are available and require prompt initiation.