Expression and role of AQP1 in cervical squamous carcinoma and its precancerous lesions

作     者：Liu Ming Sun Ying Zhang Jian Wang Rong Gao Ya 

作者机构：Department of Gynecology and Obstetrics Second Affiliated Hospital Xi ＇an Jiaotong University Xi＇an 710004 China Department of Pathology First Affiliated Hospital Medical College Xi＇an Jiaotong University Xi＇an 710061 China 

出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)

年 卷 期：2008年第23卷第4期

页      面：237-242页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Fund of Science and Technology Development Program of Shaanxi Province (2005K09-G6  2005K09-G9) 

主　　题：Aquaporin 1 Cervical squamous carcinoma Immunohistochemistry 

摘      要：Objective： To investigate the expression of aquaporin 1 in cervical squamous carcinomas （CSC） and cervical precancerous lesions, and the relationship between the tumor clinicopathological parameters, prognosis and the expression of AQP1. Methods： Immunohistochemical method （EliVision） was used to detect the expression of AQP1 in samples from 106 patients [20 with normal cervical tissue, 30 with cervical intraepithelial neoplasia （stage Ⅰ and Ⅱ） and 56 with CSC]. Survival analysis was performed by Kaplan-Meier method. Results： AQP1 protein was expressed in vascular endothelia of all samples. It showed upregulation of AQP1 expression in CSC. There was a significant difference between CSC and normal cervical tissues （P〈0.05）. AQP1 was expressed in some tumor cells and unexpressed in normal squamous epithelial cells. And APQl-expressing tumor cells were positively related to lymph node metastasis. Patients with APQl-expressing tumor cells had the lower survival rate than the ones without. Conclusion： Abnormal expression of AQP1 plays an important role in the development of CSC. Positive expression of AQP1 in tumor cells maybe enhances tumor metastasis and could be used as a marker for tumor prognosis.