Synthesis, Crystal structure and Antioxidant of 3,5-Dihydroxy-N′-(5-bro-2-hydroxybenzylidene)benzohydrazide Hydrate

作     者：孙振高 连方 张建伟 孙金龙 郭颖 张宁 刁云鹏 

作者机构：Affiliated Hospital of Shandong University of Traditional Chinese Medicine&Pharmaceuticals Shandong University of Traditional Chinese Medicine&Pharmaceuticals College of PharmacyDalian Medical University 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2012年第31卷第9期

页      面：1309-1314页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China (No. 30772601) Shandong province natural funded Projects (No. Q2008C17) Shandong province traditional Chinese medical science and technology development programs (No. 2009-038) 

主　　题：Schiff base compound crystal structure antioxidant activity 

摘      要：A new compound, 3,5-dihydroxy-N′-（5-bro-2-hydroxybenzylidene）benzohydrazide hydrate, has been synthesized and characterized by single-crystal X-ray diffraction. The title compound crystallizes in a monoclinic system, space group P21/c with a = 14.267（6）, b = 8.079（4）, c = 13.157（6） , β = 108.114（4）, Z = 4, V = 1441.4（11） 3, Dc = 1.701 g/cm3, F（000） = 744.0, μ = 2.878 and S = 1.021. The final R = 0.0457 and wR = 0.1149 for 3500 observed reflections with I 〉 2 （I）. The ability with which the compound scavenges free radicals of ABTS and DPPH, IC50, is 34.13 and 101.6 μM, respectively.