Supercritical Carbon Dioxide Extraction of Andrographolide from Andrographis paniculata： Effect of the Solvent Flow Rate, Pressure, and Temperature

作     者：A.C. Kumoro Masitah Hasan 

作者机构：Department of Chemical Engineering Faculty of Engineering Diponegoro University SH Road Tembalang Se-.marang 50139 Indonesia Department of Chemical Engineering Faculty of Engineering University of Malaya Kuala Lumpur 50603 Malaysia 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2007年第15卷第6期

页      面：877-883页

核心收录：

学科分类：081704[工学-应用化学] 08[工学] 0817[工学-化学工程与技术] 081701[工学-化学工程] 

基　　金：Supported by the Intensification of Research in Priority Areas Project (IRPA) Ministry of Science, Technology and Innovation,Malaysia (No.09-02-03-0101-EA0001) 

主　　题：supercritical carbon dioxide extraction andrographolide Andrographis paniculata 

摘      要：Andrographis paniculata Nees has been extensively used for traditional medicine and help against fever dysentery, diarrhoea, inflammation, and sore throat. In this study, andrographolide, the main component of this plant was extracted from the leaves of A. paniculata using supercritical carbon dioxide. The operating pressures were varied from 7.50 to 20MPa, the temperatures were varied from 30℃ to 60℃, and the flow rates were varied from 0.5 to ***^-1. The best extraction condition occurred at 10MPa, 40℃, and a flow rate of ***^-1 for a 3g sample of A. paniculata ground-dried leaves. The measured extraction rate was found to be about 0.0174g of andrographolide per gram of andrographolide present in the leaves per hour of operation. The future studies must focus on the interaction between the various operating parameters such as temperature, pressure, and flow rate of supercritical carbon dioxide.