Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57blks/j Db/db mice

作     者：Juane Li Tonghua Liu Lei Wang Xiangyu Guo Tunhai Xu Lili Wu Lingling Qin Wen Sun 

作者机构：Shaanxi Provincial People's Hospital Xi'anShaanxi 710068 China Beijing University of Chinese Medicine Beijing 100029 China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2012年第32卷第3期

页      面：446-452页

核心收录：

学科分类：0710[理学-生物学] 081702[工学-化学工艺] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071002[理学-动物学] 

基　　金：Supported by International Science and Technology Cooperation Project(grant number 2009DFA31520) Innovation Team Project of Beijing University of Chinese Medicine (2011-CXTD-19) Beijing Municipal Education Commission(2011) 

主　　题：Cinnamaldehyde Diabetes mellitus,Type 2 Insulin resistance 

摘      要：OBJECTIVE:To investigate the effects of cinnamaldehyde(CA),an active and major compound in cinnamon,on glucose metabolism and insulin resistance in C57BLKS/J db/db ***:Sixteen male C57BLKS db/db mice were randomly divided into control and CA treatment *** was given(20 ***-1,p.o.) for 4 *** water was given to control and db/+ ***,the levels of fasting blood glucose(FBG),fasting serum insulin,triglyeride,cholesterol,low-density lipoprotein-cholesterol(LDL-C),high-density lipoprotein-cholesterol(HDL-C),and free fatty acids(FFA),as well as the mRNA content of adiponectin and tumor necrosis factor(TNF)-α in adipose tissue,glucose transporter type 4(GLUT-4) in skeletal muscle,and protein expressions of Akt,phospho-Akt(Thr308),AMPKα,phospho-AMPKα(Thr172) in skeletal muscle were ***:1) CA decreased serum levels of FBG and insulin as well as body weight in db/db mice;2) CA increased serum HDL-C levels;3) CA significantly decreased the mRNA expression of TNF-α in adipose tissue and upregulated mRNA expression of GLUT-4 in skeletal muscle;4) protein expression of p-Akt was increased in CA-treated mice,but Akt,AMPKα and p-AMPKα showed no ***:CA has antihyperglycemic and antihyperlipidemic actions in db/db mice and could be useful in the treatment of type-2 diabetes.