Insulin resistance in H pylori infection and its association with oxidative stress

作     者：Mehmet Aslan Mehmet Horoz Yasar Nazligul Cengiz Bolukbas F Fusun Bolukbas Sahbettin Selek Hakim Celik Ozcan Erel 

作者机构：Department of Internal Medicine Faculty of Medicine Harran University Sanliurfa Turkey Department of Gastroenterology Faculty of Medicine Harran University Sanliurfa Turkey Department of Clinical Biochemistry Faculty of Medicine Harran University Sanliurfa Turkey 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第42期

页      面：6865-6868页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Hpylori Insulin resistance Total antioxidant capacity Total oxidant status Oxidative stress index 

摘      要：AIM: To determine the insulin resistance (IR) and oxidative status in H pylori infection and to find out if there is any relationship between these parameters and insulin resistance. METHODS: Fifty-five H pylori positive and 48 H pylori negative patients were enrolled. The homeostasis model assessment (HOMA) was used to assess insulin resistance. Serum total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined in all subjects. RESULTS: The total antioxidant capacity was significantly lower in H pylori positive group than in H pylori negative group (1.36 ± 0.33 and 1.70 ± 0.50, respectively; P 0.001), while the total oxidant status and oxidative stress index were significantly higher in H pylori positive group than in H pylori negative group (6.79 ± 3.40 and 5.08 ± 0.95, and 5.42 ± 3.40 and 3.10 ± 0.92, respectively; P 0.001). Insulin resistance was significantly higher in H pylori positive group than in H pylori negative group (6.92 ± 3.86 and 3.61 ± 1.67, res- pectively; P 0.001). Insulin resistance was found to be significantly correlated with total antioxidant capacity (r = -0.251, P 0.05), total oxidant status (r = 0.365, P 0.05), and oxidative stress index (r = 0.267, P 0.05). CONCLUSION: Insulin resistance seems to be associated with increased oxidative stress in H pylori infection. Further studies are needed to clarify the mechanisms underlying this association and elucidate the effectof adding antioxidant vitamins to H pylori eradication therapy on insulin resistance during H pylori infection.