An Approach to the Core Structure of CP-225,917

作     者：ZHOU Zhi-Ming Derrick L. J. Clive 

作者机构：Pharmaceutical Center Beijing Institute of Technology Beijing 100081 Department of Chemistry University of Alberta Edmonton Alberta Canada T6G 2G2 

出 版 物：《有机化学》 (Chinese Journal of Organic Chemistry)

年 卷 期：2003年第23卷第Z1期

页      面：45-46页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：natural product total synthesis model compound 

摘      要： The complex natural product CP-225, 917 (1), which is an inhibitor of Ras fanesyl tranferase,[1～3] has at tracted much attention of several groups for its total synthesis. Our own approach is based on siloxy Cope rearrangement, which could be accomplished thermally in very good yield (99%) to from 10 to 11,[4] a model compound lacking the side arms of the natural product. Its synthetic route from 6 is shown.……