Social dominance-related major urinary proteins and the regulatory mechanism in mice

作     者：Huifen GUO Qi FANG Ying HUO Yaohua ZHANG Jianxu ZHANG 

作者机构：State Key Laboratory of Integrated Management of Pest Insects and Rodents in AgricultureInstitute of ZoologyChinese Academy of SciencesBeijingChina 

出 版 物：《Integrative Zoology》 (整合动物学（英文版）)

年 卷 期：2015年第10卷第6期

页      面：543-554页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 0905[农学-畜牧学] 0906[农学-兽医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB11010400) the China National Science Foundation(31301887) the Foundation of State Key Laboratory of IPM(ChineseIPM1403) We especially thank Jinhua Zhang for assistance with animal care,sample collecting and surgery 

主　　题：androgen corticosterone corticotropin releasing hormone receptor 2 major urinary proteins social rank 

摘      要：Major urinary proteins(MUPs)have been proven to be non-volatile male pheromones in ***,we aimed to elucidate the relationship between MUPs and dominance hierarchy,and the underlying molecular ***–submission relationship was established by chronic dyadic *** found that at the urinary protein level and hepatic mRNA level,the expression of major MUPs,including Mup20,was enhanced in dominant males compared with subordinate males,indicating that MUPs might signal the social status of male ***,the mRNA level of hepatic corticotropin releasing hormone receptor 2(CRHR2)was higher in subordinate male mice than in dominant male *** also enhanced the expression of CRHR2,but suppressed that of ***2 agonist treatment reduced the expression of MUPs in ***,male social status failed to exert significant influence on serum testosterone and corticosterone as well as the mRNA expression of their *** findings reveal that some MUPs,especially Mup20,might constitute potential dominance pheromones and could be downregulated by hepatic CRHR2,which is possibly independent of androgen or corticosterone systems.