Long-term persistence of T cell memory to HBsAg after hepatitis B vaccination
Long-term persistence of T cell memory to HBsAg after hepatitis B vaccination作者机构：ShenyangCenterforDiseaseControlandPreventionShenyang110031LiaoningProvinceChina DepartmentofGastroenterologyUniversityHospitalUtrechttheNetherlands NetherlandsCancerInstituteAmsterdamtheNetherlands
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2004年第10卷第2期
页 面：260-263页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
主 题：乙型肝炎病毒 乙肝表面抗原 T细胞存贮器 存活率 血清学检查 细胞增殖
摘 要：AIM:To determine if the T cell memory to HBsAg can persist for a long time after hepatitis B (HB) ***: Thirty one vaccine recipients who werehealthcare workers (18 females and 13 males aged 34-58 years) from Utrecht University Hospital, Netherlands, and had previously received a standard course of vaccination for hepatitis B were investigated and another 9 unvaccinated healthy volunteers from the same hospital were used as the *** samples were taken just before the experiment to test serum anti-HBs levels and the subjects were classified into different groups according to their serum titers of antiHBs and vaccination *** peripheral blood mononuclear cells (PBMC) were isolated from freshly heparinized venous blood and the proliferative response of T lymphoo/tes to the recombinant hepatitis B surface antigen (HBsAg) was ***: Positive serum anti-HBs was found in 61.3%(19/31) vaccine recipients and a significant in vitro lymphocyte proliferative response to recombinant HBsAg was observed in all the vaccinees with positive *** anti-HBs level≤10IU/L was found in 38.7% (12/31) *** this study, we specially focused on lymphocyte proliferative response to recombinant HBsAg in those vaccine recipients with serum anti-HBsAg less than 10IU/*** of them had received a standard course of vaccination about 10 years before. T lymphocyte proliferative response was found positive in 7 of the 12 vaccine *** results confirmed that HBsAg-specific memory T cells remained detectable in the circulation for a long time after vaccination,even when serum anti-HBs level had been ***: The T cell memory to HBsAg can persist for at least 10 years after HB vaccination. Further booster injection is not necessary in healthy responders to HB vaccine.
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