Cardioprotective effect of Urena lobataleaves extract on diabetic rats

作     者：Chandra Analis Ahmat Baihaki Elok Zakiyyatu Sholehah Yudi Purnomo 

作者机构：School of Medicine Malang Islamic University Indonesia 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2015年第29卷第S1期

页      面：118-119页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The project supported by Ministry Education of Indonesia 

主　　题：U.lobata diabetic cardioprotective SOD MDA TNF-α 

摘      要：OBJECTIVE To know cardioprotective effect of *** extract on diabetic *** This study uses control group post test only with male sprague dawley *** rats was induced by high fructose diet(HFD)and single dose streptozotocin 25mg·kg-1 bw intra *** rat was administrated orally with water extract of *** in concentrations of 250,500 and 1000mg·kg-1 bw for 4 *** scarifying,heart organ were collected and then superoxyde dismutase(SOD)heart level,malondialdehyda(MDA)and tumor necrosis factor-alpha(TNF-α)were *** data was analyzed using ANOVA test continued with LSD test(P0.05).RESULTS The oral administration of *** extract 250,500,and 1000mg·kg-1 bw were able to increase SOD heart level about 40%,50% and 70% respectively compared to diabetic group(P0.05),while the MDA heart level was decreased by 60%,90% and 110%(P0.05)*** supplementation of water extract from *** dose of 250,500 and 1000mg·kg-1 bw were also decrease TNF-αheart level approximately 20%,40% and 60% compared to control group(P0.05).In diabetic groups,SOD heart level was decreased compared to normal group(P0.05)while the MDA and TNF-αwere increased(P0.05).CONCLUSION *** extract acts as cardioprotector on diabetic rats by increasing of SOD heart level,decreasing of MDA heart level and TNF-α.This effect may be related to active compounds that act as an antioxidant and anti-inflammatory in *** extract.