γ-谷氨酰胺转移酶可作为α-干扰素和利巴韦林治疗持续性病毒应答的丙肝患者的独立预测因子

作     者：Villela-Nogueira C.A. Perez R.M. De Segadas Soares J.A. Moraes Coelho H.S. 徐瑞 

作者机构：Rua Pinto Guedes 140/501 CEP 20511-320 Rio de Janeiro BrazilDr. 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2006年第2卷第1期

页      面：48-48页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：丙肝患者 病毒应答 α-干扰素 治疗持续性 谷氨酰胺转移酶 病毒基因型 慢性丙肝 肝脏组织学 组织学 

摘      要：Background: Recently, gamma-glutamyl transferase (GGT) has been investigated as a predictive factor for therapy response in hepatitis C patients, but so far its value in pretreatment screening has not been established. Therefore, this study aimed at evaluating GGT as an independent predictive factor for the response to treatment with interferon-α and ribavirin in hepatitis C virus (HCV)infected patients. Methods: Naive chronic hepatitis C patients undergoing a 6-month follow-up after interferon-alpha and ribavirin therapy had their sustained virologic response (SVR) analyzed according to age, sex, body mass index, GGT levels, genotype, and liver histology by use of a multivariate logistic regression model. Results: Of the 211 patients studied with amean age of 48 ± 10 years, 125 (59% )were males. Overweight was detected in 47% of patients. Genotype 1 was detected in 141 (75% ) of the 187 patients tested. Cirrhosis was present in 67 (32% ). A high pretreatment GGT level was observed in 134 (63% ). SVR was obtained in 84 (40% ) patients. In the final logistic regression model, the variables independently associated with SVR were GGT (P 0.001), genotype (P 0.001), and liver histology (P 0.001). Conclusion: A normal GGT level is an independent predictive factor for SVR in HCV-infected patients and should be considered for pretreatment screening.