A new convenient asymmetric approach to herbarumin Ⅲ

作     者：Xue Song Chen Shi Jun Da Li Hong Yang Bo Yan Xu Ztfi Xiang Xie Ying Li 

作者机构：The State Key Laboratory of Applied Organic Chemistry Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第3期

页      面：255-257页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：The project was supported by the National Natural Science Foundation of China(No.20672050) 

主　　题：Herbarumin Ⅲ Asymmetric allylation Modified Julia olefination Yamaguchi's macro-lactonization 

摘      要：The asymmetric total synthesis of herbarumin Ⅲ 3, a naturally occurred phytotoxin, along with 8-epi-herbantmin Ⅲ 22, was succeeded in 12 steps from n-butyraldehyde based on Brown＇s asymmetric allylation, taking modified Julia olefination and Yamaguchi＇s macro-lactonization as key steps.