Identification and Determination of Nicorandil and its Degradation Products by HPLC and GC/MS

作     者：Zhong Zhou CHENG Ze Hui JIA Yan CHEN Li Ying CHEN Hua LI 

作者机构：Institute of Analytical Science Northwest University Xi＇an 710069 Xi＇an Libang Pharmaceuticals Co. Ltd Xi＇an 710075 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第8期

页      面：1057-1060页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.20445002) the Science Foundation of Shannxi province(No.2005B27) 

主　　题：Nicorandil degradation HPLC GC/MS UV. 

摘      要：A rapid and sensitive HPLC-DAD method is developed for simultaneous determination of nicorandil and its degradation products, N-（2-hydroxyethyl） nicotinamide, nitrate ion and nicotinic acid, using nicotinamide （NT） as internal standard, at wavelength 204 nm. Nicotinic acid is identified by HPLC and GC/MS. The method can also be applied to study kinetic of degradation processes of nicorandil in storage.