Identification and Determination of Nicorandil and its Degradation Products by HPLC and GC/MS
Identification and Determination of Nicorandil and its Degradation Products by HPLC and GC/MS作者机构:Institute of Analytical Science Northwest University Xi'an 710069 Xi'an Libang Pharmaceuticals Co. Ltd Xi'an 710075
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2006年第17卷第8期
页 面:1057-1060页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学]
基 金:supported by the National Natural Science Foundation of China(No.20445002) the Science Foundation of Shannxi province(No.2005B27)
主 题:Nicorandil degradation HPLC GC/MS UV.
摘 要:A rapid and sensitive HPLC-DAD method is developed for simultaneous determination of nicorandil and its degradation products, N-(2-hydroxyethyl) nicotinamide, nitrate ion and nicotinic acid, using nicotinamide (NT) as internal standard, at wavelength 204 nm. Nicotinic acid is identified by HPLC and GC/MS. The method can also be applied to study kinetic of degradation processes of nicorandil in storage.