Systemic Lupus Erythematosus Complicated with Femoral Head Ischemic Necrosis Treated by Chinese Medicine Therapy for Activating Blood and Dredging Collaterals Method

作     者：汪卫 于健宁 陶筱娟 

作者机构：Departement of Rheumatology Immunology and NephropathyZhejiang Provincial Hospital of Integrated Chinese and Western Medicine 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2011年第17卷第3期

页      面：105-110页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：systemic lupus erythematosus femoral head ischemic necrosis Chinese medicine activating blood and dredging collaterals 

摘      要：Objective：To observe the effect and mechanism of Chinese medicine therapy for activating blood and dredging collaterals（ABDC） on treating systemic lupus erythematosus complicated with avascular necrosis of the femoral head（SLE-ANFH）.Methods：Thirty-four patients（51 joints） with SLE-ANFH were assigned by a random number table to two groups：22 patients（32 joints） in the treatment group and 12 patients （19 joints） in the control *** received Western medical conventional treatment for anti-inflammation and immunosuppression,but an additional Chinese medicine decoction prescribed based on ABDC principle was administered to patients in the treatment *** observation on the patients＇ condition and therapeutic effect lasted for 3 ***：The patients＇ conditions in the two groups,as assessed by Association for Research Circulation Osseous（ARCO） staging,were similar before *** treatment,comparison between groups showed significant difference（P0.05）,and the raised Harris functional scores in the treatment group were higher than that in the control group（P0.01）.The post-treatment symptom improving rate in the treated group was 72.73%,which was higher than that in the control group（50.00%,P0.05）.Moreover,the former was superior in improving hematologic and hemorrheologic parameters in terms of prolonging activated partial thromboplastin time,lowering whole blood middle/low shear viscosity,and plasma viscosity（P0.05 or P0.01）. Two patients in the control group but none in the treatment group received hip joint replacement operation during the observation ***：Chinese medicine ABDC therapy could effectively alleviate clinical symptoms and improve joint function of patients with *** mechanism may be related to its effects on improving high coagulation manner and trend for getting embolism.