偶发轻度认知功能障碍预后与病例定义的关系

作     者：Fisk J.D. Rockwood K. 王孝文 

作者机构：Capital District Health Authority 1421-5955 Veterans’Memorial Lane Halifax NS B3H 2E1 Canada 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第11期

页      面：44-45页

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：病例定义 记忆障碍 相对风险 诊断标准 诊断特征 常因 本项 过渡状态 

摘      要：Definitions of mild cognitive impairment (MCI) vary, yielding conflicting results. For example, case definitions affect prevalence but not outcomes in prevalent cases. Our objective was to determine whether variation in case definitions affects outcomes in incident cases of MCI. The 5 year risks of death, institutionalisation, and dementia were evaluated in clinically examined incident MCI cases in the Canadian Study of Health and Aging. The definition of MCI was varied so as to include or relax combinations of diagnostic features from consensus criteria. Relative risks (RR) of each adverse outcome were highest in MCI case definitions that required subjective memory complaints (for example, RR of dementia=26.4-38.7). Although each MCI definition conferred an increased risk of dementia, for each case definition 20-30%of survivors had no cognitive impairment at follow up. In this population based study, MCI represented a transitional state, but was heterogeneous, with substantial proportions recovering, regardless of how MCI was defined. Factors associated with recovery and non-progression in MCI require elucidation.