Synthesis and relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) complexes with dihydropyridine derivative of diethvlenetriaminepentaacetic acid

作     者：CHANG Jianhua ZHENG Shuzhan JIAN Yajun BAI Yinjuan ZHANG Shiping 

作者机构：Department of Chemistry Northwest University Xi'an 710069 China Department of Chemistry Northwest University Xi'an 710069 China Department of Chemistry Northwest University Xi'an 710069 China Department of Chemistry Northwest University Xi'an 710069 China Department of Chemistry Northwest University Xi'an 710069 China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2005年第48卷第z1期

页      面：93-96页

核心收录：

学科分类：07[理学] 08[工学] 0703[理学-化学] 

基　　金：the Science Foundation of Shaanxi Province(2002B02) 

主　　题：diethylenetriaminepentaacetic acid, dihydropyridine, magnetic resonance imaging contrast agent, relaxivity. 

摘      要：A novel ligand of DTPA-dihydropyridine derivative was synthesized by reaction of DTPA-dianhydride with 4-aniline-1,4-dihydropyridine. Its complexes of gadolinium, manganese and iron were prepared. Their spin-lattice relaxivities (T1) were investigated. The results show that the NMR T1 relaxivitives (R1) for complexes of Fe(Ⅲ), Mn(Ⅱ) are less than that of Gd(Ⅲ) complex,which has a high relaxivity (R1) on the surrounding water protons, indicating that the Gd(Ⅲ) complex possesses the precondition to be contrast agents for magnetic resonance imaging.