Stereoselective Synthesis of N^1-Lyxitol Inosine Derivative

作     者：Li Jun HUANG Yan PANG Ji Mei MIN Li He ZHANG 

作者机构：National Research Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2001年第12卷第7期

页      面：575-578页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Notes 

主　　题：Cyclic ADP-ribose analogues synthesis X-ray crystallographic analysis 

摘      要：1,4-anhydro-2-trifiyl-3,5-O-benzenylidene-L-xylitol (5) was constructed in six steps from protected D-xylose. Substitution of 5 with protected 8-bromoinosine 6 gave the key intermediate 5 -O-TBS-2 ,3 -di-O-acctyl-N-1-(2 -deoxy-1 ,4 -anhydro-3 ,5 -O-benzenylidene (14). Selective removal of 5 -O-TBS-group gave the corresponding though phosphorylation which was characterized by X-ray crystallographical analysis.