STUDY ON INHIBITION OF PANCREATIC EXOCRINE SECRETION BY SOMATOSTATIN IN RATS

作     者：何晓东 M.T.Nelson H.Debas 

作者机构：GastrointestinalResearchLaboratoryDepartmentofSurgeryandPhysiologyUniversityofCafiforniaSchoolofMedicineSanFranciscoCalifornia 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：1996年第11卷第3期

页      面：166-169页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：amylase pancreas somatostatin 

摘      要：We used a potent and specific monoclonal antibody to somatostatin to test the physiologic inhibitory role of the tetradecapeptide somatostatin on pancreatic *** immunoneutralization increased both the total amylase and volume of pancreatic ***-A receptor antagonism abolished the stimulatory effect of somatostatin *** conclude that somatostatin tonically inhibits pancreatic secretion in fasted rats via inhibition of the release or action of ***,the source of these peptides is likely islet delta cells and intrapancreatic neurons,respectively.