痤疮的一个预后因素:遗传

作     者：Ballanger F. Baudry P. N' Guyen J.M. B. Dré no 罗素菊 徐波 

作者机构：Department of DermatologyUniversity Hospital Place Alexis Ricordeau FR- 44035 Nantes France 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第4期

页      面：47-48页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：痤疮患者 青春期前 亚组 流行病学研究 中更 

摘      要：Background: The role of heredity in acne severity and therapeutic response remains unclear. Objective: A prospective epidemiologic study was performed to compare clinical and evolutive features of acne and response to treatment in 151 patients with acne with (A+ ) or without (A- ) family history of acne. Methods: A+ and A- patients were compared on clinical and therapeutic criteria. A+ patients were then distributed into subgroups (M+ , F+ , M+ F+ ) following the origin of family history (father: F, mother: M). Results: The clinical profile was similar in the A+ and A- populations. Acne occurred earlier and more often before puberty in the A+ population, in which oral treatments and relapse after isotretinoin were more frequent. Retentional lesions (number and extent) were more important in the M+ and M+ F+ populations. Conclusion: This study confirms the importance of heredity as a prognostic factor for acne. Family history of acne is associated with earlier occurrence of acne, increased number of retentional lesions and therapeutic difficulties.