The Antagonistic Effects of L-dopa and Eserine on Al-induced Neurobehavioral Deficits in Rats

作     者：ZHENGYu－Xin LIANGYou－Xin 

作者机构：DeartmentofOccupationalHealthShanghaiMedicalUniversityShanghai200032China DeartmentofOccupational 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1998年第11卷第4期

页      面：321-330页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

主　　题：铝/拮抗剂和抑制剂 铝/毒性 体重/药物作用 胆碱酯酶抑制剂/治疗应用 多巴胺药/治疗应用 药物评价 临床前 左旋多巴/治疗应用 迷宫学习/药物作用 记忆/药物作用 神经毒素类/拮抗剂和抑制剂 神经毒素类/毒性 毒扁豆碱/治疗应用 大鼠 Sprague-Dawley 动物 女(雌)性 大鼠 

摘      要：The main goals of the study were to elucidate the mechanism of Al-induced behavioral toxicity and to explore the possible link between the changes in the metabolism of monoaminergic or cholinergic transmitters and neurobehavioral *** groups (12 rats in each group) were fed with aluminum chloride in drinking water (1600 mg/l) ad libitum through a 90-day exposure Period. The controls were fed with distilled water. From the 60th to 90th day of treatment, two of the three Al-treated groups were administered with L-dopa (220 mg/kg. bw) and eserine (0. 4 mg/kg. bw)by gavage, respectively. A twcritem neurobehavioral test battery consisting of step down test and Morris water maze task was used for rats after three months treatment. In thestepdown test, markedly shortened the step-down latency (SDL) and the number of step-down (NSD) were observed in the Al-treated group (P 0. 05, vs control ). In eserine and L-dopa antagonized groups, the mean escape latencies of Morris water maze approached a level close to that of the controls (P 0. 05). The results showed that the Al-induced memory and learning impairment could be reduced by L-dopa or eserine. It is suggested that the depletion of dopaminergic and cholinergic transmitters in the central nervous system might play an important role in Al-induced neurotoxicty