脑白质高信号与身体残疾和运动功能降低有关

作     者：Sachdev P.S. Christensen H. Jorm A.F. 袁海峰 

作者机构：NPI Prince o f Wales Hospital Barker StreetRandwick NSW 2031 Australia Prof. 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第7期

页      面：22-22页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：脑白质 认知功能 身体残疾 钉板 信息处理速度 muscular 脑萎缩 FLAIR assessed 工作记忆 

摘      要：Objective: To determine the impact of white matter hyperintensities(WMHs) on p hysical health and cognitive function in 60-64 year old individuals residing in the community. Methods:A subsample of 478 persons aged 60-64 from a larger com munity sample underwent brain magnetic resonance imaging(MRI) scans. WMHs on T2 weighted FLAIR (fluid attenuated inversion recovery) MRI scans were assessed usi ng anautomated procedure. Subjects were assessed for global cognitive function, episodic memory, working memory (digit span),information processing speed (Symbo l Digit Modalities Test;SDMT), fine motor dexterity (Purdue Pegboard), and grip strength, and completed the Physical Component Summary of the Short Form Health Survey (SF-12). Regression analyses were used to examine the effect of WMHs on physical and cognitive function. Results: Deep and periventricular WMHs were pre sent in all subjects, with women having slightly more lesions than men. WMHs wer e significantly associated with poorer reported physical health on the SF-12 sc ale, after adjusting for depression, cognitive function, and brain atrophy. WMHs were also related to lower scores on the Purdue Pegboard test, grip strength, c hoice reaction time, and SDMT, but not on tests of episodic memory, working memo ry, general intellectual function,and global cognitive function. On regression a nalyses, the Purdue Pegboard test and grip strength were related to physicaldisa bility. Conclusion: WMHs are common, albeit mild, in middle adult life. They are associated with physical disability,possibly through reduced speed, fine motor coordination, and muscular strength. They are also related to slowed information processing speed but not other cognitive functions.