Lipoprotein metabolism in nonalcoholic fatty liver disease

作     者：Zhenghui Gordon Jiang Simon C. Robson Zemin Yao 

作者机构：Department of MedicineBeth Israel Deaconess Medical Center/Harvard Medical SchoolBostonMAUSA Division of GastroenterologyCLS612Beth Israel Deaconess Medical Center/Harvard Medical SchoolBostonMAUSA Department of BiochemistryMicrobiology and ImmunologyOttawa Institute of Systems BiologyUniversity of OttawaOttawaOntario KIH 8M5Canada 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2013年第27卷第1期

页      面：1-13页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：nonalcoholic fatty liver disease (NAFLD) hepatic steatosis nonalcoholic steatohepatitis apolipo-protein lipoprotein metabolism very low density lipoprotein 

摘      要：Nonalcoholic fatty liver disease （NAFLD）, an pathologies characterized by fatty accumulation in escalating health problem worldwide, covers a spectrum of hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellu- lar role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metab- olism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD.