Applying genetic algorithms to the study of protein mutation theory

作     者：Zhirong Sun Hao Han Wang 

作者机构：Tsing Hua Univ Dept Biol Sci & Biotechnol Beijing 100084 Peoples R China 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：1998年第43卷第23期

页      面：1977-1982页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina (GrantNo .396 70 189) 

主　　题：genetic algorithm two_dimensional lattice model single mutation double mutation. 

摘      要：Genetic algorithms were applied to the study of simulation of protein mutation carried out on two_dimensional lattice model; to the study of effects of single mutation and double mutation on protein folding and protein structure stability. It is found that in two_dimensional lattice models, replacement of inner core hydrophobic residue by hydrophilic residue will result in reduction of protein stability; at the same time the number of residues of protein surface relatively grows with increase of protein chain length; and most mutations occur in residues of protein surface, these mutations are all neutral and have no effects on protein natural structure. The two mutations of double mutation are interactive and related to each other.