Improvement of Mechanical Stability for Single Unit Recording Based on Skull Cap in Living Chinchilla
作者机构：Department of Neurosurgerythe Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Otolaryngology-Head&Neck SurgeryJohns Hopkins University School of MedicineBaltimore 21205USA Division of Health Sciences InformaticsJohns Hopkins University School of MedicineBaltimore 21205USA School of Mathematics and StatisticsCentral China Normal UniversityWuhan 430079China Department of Otolaryngology-Head&Neck Surgerythe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2019年第39卷第1期
页 面：166-172页
核心收录：
学科分类：10[医学]
基 金：National Institutes of Health, NIH National Institute on Deafness and Other Communication Disorders, NIDCD
主 题：single unit recording skull cap mechanical stability improvement semicircular canal neurons
摘 要：Three-point head fixation was constructed to provide mechanical stability for single unit recording(SUR)on vestibular sensory system in living chinchilla ***,it is no more qualified to this work when the stimulation intensity becomes large because of frequent unit losing and neuron damage,which strongly implies that the mechanical stability has been broken during the ***,we constructed a novel hea0 fixation(skull cap assistant head fixation)provided by skull cap on the basis of three-point head fixation in order to improve the mechanical stability for SUR under the stimulation with large *** large area bone connection is the feature and advantage of this improved method,which directly fixes the tested local nervous tissue and microelectrode in an intact stable system through skull cap except two ear bars and a tube face *** data exhibited that skull cap assistant head fixation could significantly improve the success rate of neural response activity recording in the population of semicircular canal neurons under the stimulation with large intensity(amplitudd 00 deg/s).Based on the analysis of neural response activity and noise base-line during stimulation,our data further indicated that this method could significantly improve the mechanical stability for SUR during high-speed motion stimulation on vestibular system in living *** cap assistant head fixation extends the application of SUR on vestibular neuron in linear response range and provides a solid foundation for electrophysiological research on vestibular sensory system in fhrther studies.
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