Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study

作     者：Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye 

作者机构：Department of Epidemiology University of Groningen University Medical Center Groningen Center for Medical Imaging-North East Netherlands University of Groningen University Medical Center Groningen Department of RadiologyTianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin’s Clinical Research Center for Cancer Department of Epidemiology and Biostatistics Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin’s Clinical Research Center for Cancer Department of RadiologyUniversity of Groningen University Medical Center Groningen Department of Radiology Martini Hospital Department of Pulmonary Diseases University of Groningen University Medical Centre Groningen Medisch Spectrum TwenteDepartment of Pulmonology Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of Medicine Department of Radiology Shanghai Changzheng Hospital The Second Military Medical University Shanghai 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2019年第16卷第1期

页      面：181-188页

核心收录：

学科分类：10[医学] 

基　　金：a part of NELCIN-B3 project. The NELCIN-B3 project is funded by The Royal Netherlands Academy of Arts and Sciences (Grant No. PSA_SA_BD_01) Ministry of Science and Technology of the People’s Republic of China National Key R & D Program of China (Grant No. 2016YFE0103000) the financial support from China Scholarship Council (CSC file No. 201708340072) 

主　　题：Lung cancer lung nodules screening computed tomography China 

摘      要：Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese ***: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose ***: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and ***: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations.