IL-12 p35 silenced dendritic cells modulate immune responses by blocking IL-12 signaling through JAK-STAT pathway in T lymphocytes

作     者：Xu, H. Zhang, Y. H. Hua, Y. B. Chen, T. Wang, H. Q. Wu, W. X. 

作者机构：Nanjing Med Univ Affiliated Hosp Dept Gen Surg Nanjing 210009 Jiangsu Prov Peoples R China 

出 版 物：《南京医科大学学报（自然科学版）》 (Journal of Nanjing Medical University(Natural Sciences))

年 卷 期：2007年第27卷第4期

页      面：423-423页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主　　题：JAK-STAT路径 淋巴细胞 RNA干涉 细胞因子 移植 免疫 IL-12 p35 基因沉默 

摘      要：Dendritic cells (DC) constitute a complex system of uniquely specialized antigen-presenting cells (APC) that play crucial roles in the initiation and regulation of immune responses。Recent studies have demonstrated that DC silenced by siRNA IL-12 p35 showed tolerogenic capacity in vitro。However, their mechanism of action is not fully understood。In this study。