Study on Vip protein expression in psoriatic epidermis with the topical treatment of capsaicin ointment
Study on Vip protein expression in psoriatic epidermis with the topical treatment of capsaicin ointment作者机构：Department of Dermatology Second Hospital of Xi＇an Jiaotong University Xi＇an 710004 China
出 版 物：《Journal of Nanjing Medical University》 (南京医科大学学报（英文版）)
年 卷 期：2006年第20卷第2期
页 面：124-126页
学科分类：10[医学]
摘 要：Objective： To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods： VIP protein in active psoriatic lesions before and 30 days after the treaanent of capsaicin ointment was detected by immunohistochemistry. Results： There was positive expression of VIP in all layers of psoriatic lesions epidermis （95.5 % ）, but after the treatment of capsaicin ointment, there was nearly no expression of VIP protein in epidermis（22.2% ）. Conclusion： Capsaicin inhibits proliferation and induces the differentiation of keratinocytes through down-regulating the expression of VIP in psoriatic epidermis.
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