otassium channels in airway smooth muscle and airway hyperreactivity in asthma

作     者：LIUXian-sheng XUYong-jian 

作者机构：DepartmentofRespiratoryMedicineTongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2005年第7期

页      面：574-580页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：ThisworkwassupportedbytheNationalNaturalScienc FoundationofChina(No.30270583) 

主　　题：delayed rectifier K^+ channel . large conductance Ca^(2+) activated K^+ channel . ATP sensitive K^+ channel . airway smooth muscle cell . asthma 

摘      要：Our knowledge of the physiology of ion channels has increased tremendously during the past 20 years because of the advances of the single-channel recording and molecular cloning techniques. More than 50 different identified potassium channels have already been found.1,2 They are distributed ubiquitously in wide variety of cells including airway smooth muscle （ASM） cells and inflammatory cells in airway such as eosinophils, basophils, macrophages and so on.3 Several types of K+ channels have been identified in ASM cells, e.g., a large-conductance, voltgage-dependent Ca2+-activated K+ channel(BKCa), a voltage-dependent delayed-rectifier K+ channel（Kv）, and an ATP-sensitve K+ channel(KATP).1 In such excitable cells,