High-intensity focused ultrasound in patients with late-stage pancreatic carcinoma

作     者：王晓 孙靖中 WANG Xiao;SUN Jingzhong

作者机构：济南市中心医院普外科济南250013 山东大学齐鲁医院外科济南250012 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2002年第115卷第9期

页      面：1332-1335,148页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Adult Aged Aged, 80 and over Female Humans Killer Cells, Natural Male Middle Aged Pancreatic Neoplasms Ultrasonic Therapy 

摘      要：OBJECTIVES: To observe the efficacy of high intensity focused ultrasound (HIFU) in the treatment of late-stage pancreatic carcinoma and evaluate its influence on cell-mediated immunity in the host. METHODS: Fifteen patients with late-stage pancreatic carcinoma had their tumor tissue completely destroyed with HIFU. Evaluation of efficacy was made on the basis of clinical symptom changes, variations in tumor echo, changes in pancreatic amylase, serum CA19-9 and CA242, CD3(+), CD4(+) subsets, CD4(+)/CD8(+) ratios and NK cell activity. RESULTS: Clinical symptoms such as pain were significantly alleviated, echo of tumor was enhanced with B-US, CA19-9 and CA242 were decreased and pancreatic amylase showed no change. Eating, sleeping and mental status were all markedly improved; no serious complications were seen. On the other hand, NK cell activity was significantly enhanced in 10 patients (P