A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou,China

作     者：XU Li Fang ZHOU Xiao Long WANG Qi ZHOU Ji Long LIU Ya Peng JU Qiang WANG Hui ZHANG Jin Peng WU Qing Rong LI Yi Qun XIA Yu Juan PENG Xiu ZHANG Mei Rong YU Hong Min XU Li Chun 

作者机构：School of Public Health Xuzhou Medical College Obstetrical DepartmentMaternal and Child Health Hospital of Xuzhou City 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2015年第28卷第7期

页      面：535-538页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：supported by the National Natural Science Foundations of China(No.81273103) the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD) 

主　　题：A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou,China CLP 

摘      要：In this study, we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate （NSCLP） to understand the etiology of the disease. A total of 200 NSCLP cases and 327 controls were recruited at the Maternal and Child Health Hospital of Xuzhou City. We conducted face-to-face interviews with the mothers of both cases and controls. The factors increasing the risk of NSCLP were a positive family history [odds ratio （OR）=56.74], pesticide exposure （OR=8.90）, and indoor decoration pollution （OR= 4.32）. On the other hand, the factors decreasing the risk of NSCLP were a high education level （OR=0.22） and supplementation of folic acid （OR=0.23） and multivitamins （OR=0.16）. Positive family history, pesticide exposure, and indoor decoration pollution are associated with the risk of NSCLP. In contrast, high education level and folic acid and multivitamin supplementation are protective factors against NSCLP.