关于使用缩胆囊素-8肽预防发生TPN相关的胆结石疾病失败病例
Failure of cholecystokinin-octapeptide to prevent TPN associated gallstone disease作者机构:Section of Pediatric Surgery CS Mott Children’s Hospital University of Michigan Health System Ann Arbor MI 48109 United States
出 版 物:《世界核心医学期刊文摘(儿科学分册)》 (Dkgest of the World Latest Medical Information)
年 卷 期:2005年第1卷第6期
页 面:59-60页
学科分类:1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题:缩胆囊素 TPN 失败病例 全肠道外营养 乌索脱氧胆酸 胆道系统 胆囊切除术 溶石 无症状性 腹部手术
摘 要:Gallstone formation is a common problem in neonates on prolonged courses of total parenteral nutrition (TPN). The authors hypothesized that the use of cholecystokinin- octapeptide (CCK), given at the time of TPN administration, would prevent gallstone formation in a high-risk group of patients with TPN. Aprospective, randomized, blinded, controlled trial of neonates who were on a prolonged course of TPN for prematurity (25 infants), necrotizing enterocolitis (NEC, 8 infants), or abdominal surgery (5 infants) were selected randomly to receive CCK vs placebo. Patients remained on the study until taking more than 50%of energy enterally. Children were recalled between 2 and 4 years after completing TPN for ultrasonographic examination of their hepatobiliary tree. Neonates (38 studied) required a mean (±SD) of 33 ±16 days of TPN. Cholelithiasis was detected in 4 (10%) infants. Cholecystokinin-octapeptide was not effective in preventing the formation of gallstones (3 stones in infants receiving CCK, P =.51). Diagnosis (P =.56), birth weight (P =.54), gestational age (P =.18), and duration of TPN (P =.53) did not correlate with gallstone formation. To address the management of these stones, all 4 were placed on a prolonged course of ursodeoxycholic acid (mean duration, 11.6 ±5.4 months). Two additional infants (not in the original study)-with TPN-associated gallstone disease were also given a trial of ursodeoxycholic acid. Serial ultrasounds were performed every 6 months. No patient achieved any degree of stone dissolution. One patient underwent cholecystectomy for symptomatology. Total parenteral nutrition-associated gallstones were detected in 10%of children, and most are nonsymptomatic. Cholecystokinin-octapeptide prophylaxis was not effective in preventing TPN-associated gallstones. In addition, the use of ursodeoxycholic acid did not dissolve gallstones, once identified. Future methods will be needed to address the prevention and treatment of these stones.