乳房外Paget病皮损中胰岛素样生长因子-1受体p-AKT及p-ERK1/2蛋白的表达

作     者：Moroi Y. Yasumoto S. K. Urabe 潘敏 

作者机构：Department of Dermatology Graduate School of Medical Sciences Kyushu University Maidashi 3-1-1 Higashiku Fukuoka 812-8582 Japan 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第11期

页      面：46-47页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：乳房外 p-AKT p-ERK1/2 Paget 细胞凋亡 信号转导 免疫组化染色 磷脂酰肌醇 细胞 

摘      要：Background: The insulin-like growth factor-1 (IGF-1) receptor (R)-induced phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen-activated protein kinase (MAPK)/ERK signal transduction cascade, which have critical roles in prevention of apoptosis and regulation of cell cycle progression, plays an important role in tumorigenesis. The expression of IGF-1R, AKT and ERK1/2 has been described in some human malignancies, but not in extramammary Paget’s disease (EMPD). Objectives: To study the expression of IGF-1R, p-AKT and p-ERK1/2 in EMPD and to evaluate the relationships among them. Methods: Thirty-six tissue samples of 34 patients with primary EMPD were subjected to immunohistochemical staining for IGF-1R, p-AKT and p-ERK1/2. Results: Of thirty-six EMPD tissue samples, 34, 34 and 28 were positive for IGFIR, p-AKT and p-ERK1/2 expression, respectively; 27, 23 and 17 of the 36 specimens stained positive for IGF-IR, p-AKT and p-ERK1/2 in more than half of Paget’s cells, respectively. There were significant correlations between the IGF-1R and p-AKT expression as well as between IGF-1R and p-ERK1/2 expression. Taken together, these results indicate that IGF-1R is overexpressed, and AKT and ERK1/2 are frequently phosphorylated in EMPD. Conclusions: Our study shows that the expression of IGF-1R and the induction of p-AKT and the p-ERK1/2 pathwaymay play an important role in the pathogenesis of EMPD. The IGF-IR system might be a potential therapeutic target in EMPD.