Sirtuins in B lymphocytes metabolism and function
Sirtuins in B lymphocytes metabolism and function作者机构：Department of Immunology Institute of Biomedical Sciences University of Sao Paulo Division of Nephrology School of Medicine Federal University of Sao Paulo Laboratory of Renal Physiology (LIM 16) School of MedicineUniversity of S?o Paulo
出 版 物：《World Journal of Experimental Medicine》 (世界实验医学杂志)
年 卷 期：2019年第9卷第1期
页 面：1-13页
学科分类：10[医学]
基 金：Supported by Fundacao de AmparoàPesquisa de Sao Paulo(FAPESP)under Agreements,No.2015/26682-6,No.2017/03248-4and No.2017/05264-7 financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nível Superior–Brasil(CAPES)–Finance Code 001
主 题：B cells Metabolic sensors Histone deacetylases Cancer
摘 要：Sirtuins(SIRTs) are NAD+-dependent histone deacetylases and play a role in virtually all cell biological processes. As SIRTs functions vary according to their subtypes, they can either activate or inhibit signaling pathways upon different conditions or tissues. Recent studies have focused on metabolic effects performed by SIRTs in several cell types since specific metabolic pathways(e.g., aerobic glycolysis, oxidative phosphorylation, β-oxidation, glutaminolysis) are used to determine the cell fate. However, few efforts have been made to understand the role of SIRTs on B lymphocytes metabolism and function. These cells are associated with humoral immune responses by secreting larger amounts of antibodies after differentiating into antibody-secreting cells. Besides, both the SIRTs and B lymphocytes are potential targets to treat several immune-mediated disorders, including cancer. Here, we provide an outlook of recent studies regarding the role of SIRTs in general cellular metabolism and B lymphocytes functions, pointing out the future perspectives of this field.
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