Effect of GNTI,a kappa opioid receptor antagonist,on MK-801-induced hyperlocomotion and stereotypy in mice
Effect of GNTI,a kappa opioid receptor antagonist,on MK-801-induced hyperlocomotion and stereotypy in mice作者机构：Research Center for Biotechnology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Department of Genetics and Center of Alcohol Studies Rutgers the State University of New Jersey USA
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2006年第27卷第11期
页 面：1401-1408页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：Project supported by grant from the National Natural Science Foundation of China(№30270219)
主 题：GNTI kappa opioid receptor MK-801 schizophrenia model
摘 要：Aim:To examine the effect of GNTI [5′-guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2′,3′-indolomorphinan],a selective antago-nist for the kappa opioid receptor,in the MK-801(dizocilpine maleate)-inducedbehavioral model of psychosis in schizophrenia as a way to explore the involve-ment of the kappa opioid receptor in modulating psychotic symptoms ***:Two doses of MK-801(0.3 mg/kg and 0.6 mg/kg)wereadministered by systemic injection in mice to induce psychosis-like behavior as arodent schizophrenia model,preceded by an injection of different doses of *** locomotion and stereotypy were measured as the behavioral endpoints forquantitative ***:GNTI inhibited MK-801-induced hyperlocomotionand *** particular,GNTI showed differential modulation of stereotypyinduced by 0.3 mg/kg vs 0.6 mg/kg ***:Antagonism of kappaopioid receptors attenuates MK-801-induced behavior,suggesting a potentialinvolvement of the kappa opioid receptor in psychosis-like symptoms *** appears to be a useful pharmacological tool to explore thekappa opioid receptor function in vivo.
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