猪鞭虫治疗克罗恩病

作     者：Summers R.W. Elliot D.E. Urban Jr. J.F. 雒向宁 

作者机构：James A. Clifton Ctr. Digest. Dis. Department of Internal Medicine University of Iowa 200 Hawkins Drive Iowa City IA 52242 United States Dr. 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2005年第1卷第5期

页      面：30-31页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：克罗恩病 鞭虫 实验性结肠炎 疾病活动度 免疫应答 免疫性疾病 炎症反应 个活 不良反应 下者 

摘      要：Background: Crohns disease is common in highly industrialised Western countries where helminths are rare and uncommon in less developed areas of the world where most people carry worms. Helminths diminish immune responsiveness in naturally colonised humans and reduce inflammation in experimental colitis. Thus exposure to helminths may help prevent or even ameliorate Crohns disease. Aims: The aim of the study was to determine the safety and possible efficacy of the intestinal helminth Trichuris suis in the treatment of patients with active Crohns disease. Patients: Twenty nine patients with active Crohns disease, defined by a Crohns disease activity index (CDAI) ≥220 were enrolled in this open label study. Methods: All patients ingested 2500 live T suis ova every three weeks for 24 weeks, and disease activity was monitored by CDAI. Remission was defined as a decrease in CDAI to less than 150 while a response was defined as a decrease in CDAI of greater than 100. Results: At week 24, 23 patients (79.3%) responded (decrease in CDAI 100 points or CDAI 150) and 21/29 (72.4%) remitted (CDAI 150). Mean CDAI of responders decreased 177.1 points below baseline. Analysis at week 12 yielded similar results. There were no adverse events. Conclusions: This new therapy may offer a unique, safe, and efficacious alternative for Crohns disease management. These findings also support the premise that natural exposure to helminths such as T suis affords protection from immunological diseases like Crohns disease.