Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure

作     者：Dong-Hui Huang Hao Sun Jing-Pu Shi Huang Dong-Hui;Sun Hao;Shi Jing-Pu

作者机构：Department of Clinical Epidemiology and Evidence-based Medicine Institute of Cardiovascular Diseases The First Hospital of China Medical University Shenyang Liaoning 110001 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2016年第129卷第5期

页      面：570-577页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Biomarker Diagnosis Heart Failure Meta-analysis Soluble Suppression of Tumorigenicity-2 

摘      要：Background：Many studies have explored the diagnostic performance of soluble suppression of tumorigenicity-2 （sST2） for heart failure （HF）,but the results are ***,we performed a meta-analysis to assess the role of sST2 in the diagnosis of ***：We searched PubMed,Web of Science,Cochrane Library,China National Knowledge Infrastructure,and Wanfang Database from inception to April *** that investigated the diagnostic role of sST2 for HF were *** numbers of true-positive,false-positive,false-negative,and true-negative results were extracted to calculate pooled diagnostic odds ratio （DOR） with 95% confidence interval （CI） and the summary receiver operating characteristic curve and area under the curve （AUC）.The Spearman correlation coefficient was used to check the threshold *** Cochran Q statistic （P 〈 0.05） and the inconsistency index （I2 〉 50%） were used to assess the nonthreshold ***-regression was conducted to explore the source of heterogeneity;subgroup analysis showed the results in different ***,the Deeks＇ test was performed to assess the publication ***：Nine articles including 10 studies were included in the *** pooled sensitivity was 0.84 （95% CI：0.81-0.86）,and pooled specificity was 0.74 （95% CI：0.72-0.76）.The summary DOR was 8.49 （95% CI：4.54-15.86）,and AUC was 0.81 （standard error：0.03）.The Spearman correlation coefficient identified the nonsignificant threshold effect （coefficient =0.49,P =0.148）,but the nonthreshold effect heterogeneity was significant （Cochran Q =58.52,P 〈 0.0001;I2 =84.6%）.Meta-regression found that characteristics of controls might be the suggestive source ofnonthreshold effect heterogeneity （P =0.095）.Subgroup analysis found that DOR was 5.65 and 7.86,respectively for the controls of hospital patients and healthy ***＇ test demonstrated that there was no publication bias （P =0.616）.Conclusion：The meta-analysis illustrated that sST2 migh