Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM] and GSTT1

作     者：Jian Chao Bian Fu Min Shen Li Shen Tian Ru Wang Xiao Hong Wang Gong Chao Chen Jin Bing Wang Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China Haimen Municipal Anti-Epidemic and Health Station,Haimen 226201,Jiangsu Province,China Qidong Institute for Liver Cancer,Qidong 226200,Jiangsu Province,China 

作者机构：上海医科大学 上海 江苏海门市卫生防疫站 江苏 海门 江苏启东肝癌防治所 江苏 启东 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2000年第6卷第2期

页      面：228-230页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China,No.39470628 the Scientific Foundation of Ministry of Health,China,No.96-1-189 

主　　题：liver neoplasms carcinoma hepatocellular GSTM1 GSTT1 null genotypes 

摘      要：AIM In order to study the association betweenthe null genotypes of GSTM1 and GSTT1 and thegenetic susceptibility to hepatocellularcarcinoma(HCC).METHODS The genotypes of GSTM1 and GSTT1of 63 cases of HCC and 88 controls were detectedwith the multiple PCR *** The frequency of GSTM1 nullgenotype was 57.1% among the cases,and42.0% among the controls,the difference beingstatistically significant(χ~2=3.35,P=0.067),but χ~2 value approaching the significance *** odds ratio was 1.84(95% Cl= 0.91-3.37).The frequency of GSTT1 non-null genotype was87.3% among the cases and 52.5% among thecontrols,the difference being statisticallysignificant(χ~2=11.42,P=0.0007274).The oddsratio was 4.13(95% Cl=1.64-10.70).According to the cross analysis,the GSTT1 non-null genotype was more closely associated withHCC than GSTM1 null genotype,and these twofactors play an approximate additive interactionin the occurrence of *** The persons with GSTM1 nullgenotype and GSTT1 non-null genotype have theincreased risk to HCC.