Synthesis and Antifungal Activity of Novel Chiral α-Aminophosphonates Containing Fluorine Moiety

作     者：杨松 高兴文 刁春玲 宋宝安 金林红 徐广芳 张国平 王伟 胡德禹 薛伟 周霞 卢平 

作者机构：Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for Research and Development of Fine Chemicals Guizhou University Guiyang Guizhou 550025 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2006年第24卷第11期

页      面：1581-1588页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 100701[医学-药物化学] 10[医学] 

基　　金：Project supported by the National Key Program for Basic Research (Nos. 2003CB114404  2005CCA01500)  the National Natural Science Foundation of China (No. 20362004) and the Doctoral Program Foundation of the Ministry of Education  China (No. 20040657003) 

主　　题：chiral aminophosphonate fluorine moiety antifungal activity microwave irradiation synthesis 

摘      要：Chiral α-aminophosphonates were synthesized using （R） or （S）-1-phenylethylamine in the presence of BF3·Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by ^1H NMR, ^19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α-aminophosphonates containing fluorine moiety.