Therapy of gallstone disease:What it was,what it is,what it will be
Therapy of gallstone disease:What it was,what it is,what it will be作者机构：Department of Biomedical Sciences and Human OncologyClinica Medica "A.Murri"University of Bari Medical SchoolPiazza Giulio Cesare 11Policlinico70124 BariItaly Division of Internal MedicineHospital of Bisceglievia Bovio 27970052 Bisceglie (Bari)Italy Division of Gastroenterology and HepatologyDepartment of Internal MedicineEdward Doisy Research CenterSaint Louis University School of MedicineSt.LouisMO 63104United States
出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)
年 卷 期：2012年第3卷第2期
页 面：7-20页
基 金：Supported by (in part) research grants from the Italian Ministry of University and Research (No. FIRB 2003 RBAU01RANB002) the Italian National Research Council (short-term mobility grant 2005) the University of Bari (grants No. ORBA09XZZT and No. ORBA08YHKX) (to Portincasa P) University of Bari (No. DR11598-2009) the National Institutes of Health (US Public Health Service) (research grants No. DK54012 and No. DK73917) (to Wang DQH)
主 题：Gallstones Dissolution therapy Cholecystectomy Bile acids Ezetimibe Statins Gallbladder Bile Nuclear receptors
摘 要：Cholesterol gallstone disease is a common clinical condition influenced by genetic factors,increasing age,female gender,and metabolic factors.Although laparoscopic cholecystectomy is currently considered the gold standard in treating patients with symptomatic gallstones,new perspectives regarding medical therapy of cholelithiasis are currently under discussion,also taking into account the pathogenesis of gallstones,the natural history of the disease and the analysis of the overall costs of therapy.A careful selection of patients may lead to successful nonsurgical therapy in symptomatic subjects with a functioning gallbladder harboring small radiolucent stones.The classical oral litholysis by ursodeoxycholic acid has been recently paralleled by new experimental observations,suggesting that cholesterol-lowering agents which inhibit cholesterol synthesis (statins) or intestinal cholesterol absorption (ezetimibe),or drugs acting on specific nuclear receptors involved in cholesterol and bile acid homeostasis,might be proposed as additional approaches for treating cholesterol gallstones.In this review we discuss old,recent and future perspectives on medical treatment of cholesterol cholelithiasis.
维普期刊数据库